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Loren Pickart, who found that it caused older human liver tissue to produce proteins more characteristic of younger tissue.2 3 This resulted in GHK being originally described, specifically, as a liver cell growth factor

They are designed to support overall weight management in people who meet the relevant clinical criteria

Other effects include flushing, changes in appetite, and sleepiness [13, 20]

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Currently, two ongoing clinical trials are investigating the role of GLP-1 RAs in IBD management, that would lead to further knowledge: a French study (ID NCT05196958) evaluating the safety and efficacy of GLP-1 RAs in treatment of DM2 in overweight IBD patients (115), and an American study (ID NCT06774079) comparing the efficacy of GLP-1 RAs tirzepatide versus diet in CD patients (116)